Competing risk and heterogeneity of treatment effect in clinical trials

Competing risk and heterogeneity of treatment effect in clinical trials

It has been demonstrated that patients enrolled in clinical trials frequently have a large degree of variation in their baseline risk for the outcome of interest. Thus, some have suggested that clinical trial results should routinely be stratified by outcome risk using risk models, since the summary results may otherwise be misleading. However, variation in competing risk is another dimension o...

Competing commitments in clinical trials.

Title:testing the Treatment Effect on Competing Causes of Death in Oncology Clinical Trials

Testing the treatment effect on competing causes of death in oncology clinical trials

BACKGROUND Chemotherapy is expected to reduce cancer deaths (CD), while possibly being harmful in terms of non-cancer deaths (NCD) because of toxicity. Peto's log-rank test is popular in the medical literature, but its operating characteristics are barely known. We compared this test to the most common ones in the statistical literature: the cause-specific hazard test and Gray's test on the haz...

etiology, significance, diagnosis and treatment of bruxiam

چکیده ندارد.